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Dr. Georgia Menounou

Dr. Georgia Menounou

Postdoctoral Researcher

Dublin City University

https://andrewkellettgroup.com/people#/gewrgia-menounou

Professional background: Georgia Menounou is a Postdoctoral Researcher at Dublin City University, working with Prof. Andrew Kellett on the development of advanced hybrid materials for targeted gene therapy. She is also a Co-Supervisor of the NATURE-ETN project, with over 8 years of experience in the fields of synthetic, bioorganic and biomimetic chemistry. She received her M.Sc. in 2014 at the University of Crete (Greece), working on the “Isolation and Synthesis of Natural Products with Biological Activity”. In 2015, she moved to the Institute of Organic Synthesis and Photoreactivity (ISOF), CNR, Italy as an early-stage researcher in the H2020-MSCA-ITN “ClickGene” project. She was awarded a Ph.D. in 2018, working on the development of a novel approach to antitumor strategies: how copper-based metallodrugs can target both DNA and membrane lipids by inducing modifications in their structure.

Selected publications:

  • A. C. M. Galdino, L. Viganor, M. M. Pereira, M. Devereux, M. McCann, M. H. Branquinha, Z. Molphy, S. O’Carroll, C. Bain, G. Menounou, A. Kellett, A. L. S. dos Santos, Copper(II) and silver(I)-1,10-phenanthroline-5,6-dione complexes interact with double-stranded DNA: further evidence of their apparent multi-modal activity towards Pseudomonas aeruginosa, JBIC Journal of Biological Inorganic Chemistry, 27, 201–213 (2022). https://doi.org/10.1007/s00775-021-01922-3
  • N. Zuin Fantoni, Z. Molphy, S. O’Carroll, G. Menounou, G. Mitrikas, M. G. Krokidis, C. Chatgilialoglu, J. Colleran, A. Banasiak, M. Clynes, S. Roche, S. Kelly, V. McKee, A. Kellett, Polypyridyl-Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition, Chemistry A European Journal, 27, 3, 971-983 (2021). https://doi.org/10.1002/chem.202001996
  • N. Zuin Fantoni, Z. Molphy, C. Slator, G. Menounou, G. Toniolo, G. Mitrikas, V. McKee, C. Chatgilialoglu, A. Kellett. Polypyridyl-Based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease, Chemistry A European Journal, 25, 1, 221-237 (2019). https://doi.org/10.1002/chem.201804084
  • G. Toniolo, M. Louka, G. Menounou, N. Fantoni, G. Mitrikas, E. Efthimiadou, A. Masi, M. Bortolotti, L. Polito, A. Bolognesi, A. Kellett, C, Ferreri, C. Chatgilialoglu.  [Cu(TPMA)(Phen)](ClO4)2: metallo-drug nanocontainer delivery and membrane lipidomics of a neuroblastoma cell line coupled with a liposome biomimetic model focusing on fatty acid reactivity, ACS Omega, 3, 11, 15952-15965  (2018).  https://doi.org/10.1021/acsomega.8b02526