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Dr. Joanna Kowalska

Dr. Joanna Kowalska

Assistant Professor

University of Warsaw

http://www.biogeo.uw.edu.pl/people/joannakowalska_en.html

Professional background: Joanna Kowalska is an Assistant Professor in the Faculty of Physics at the University of Warsaw (Poland). She completed her Ph.D. studies in Biophysics in 2010 under the supervision of Prof. Edward Darżynkiewicz, at the University of Warsaw. In 2018, she has been nominated to a European Inventor Award. Her research interest focuses on the design and synthesis of mRNA 5’ end (cap) analogues as reagents for preparation of mRNA molecules with application in biotechnology and medicine. She is also passionate about chemical synthesis and studying properties of biologically important nucleotides, oligonucleotides, nucleic acids and their analogues. Her research also covers topics of analysis of nucleotides and nucleic acids by NMR and mass spectrometry, as well as their cellular delivery.

Selected publications:

  • H. Zhang, M. Ociepa, M. Nassir, B. Zheng, S. Lewicki, V. Salmaso, H. Baburi, J. Nagel, S. Mirza, B. Bueschbell, H. Al-Hroub, O. Perzanowska, Z. Lin, M. A. Schmidt, M. D. Eastgate, K. A. Jacobson, C. E. Müller, J. Kowalska, J. Jemielity, P. S. Baran. Stereocontrolled access to thioisosteres of nucleoside di- and triphosphates, Nature Chemistry, 1-10 (2023). https://doi.org/10.1038/s41557-023-01347-2
  • M. Warminski, A. Mamot, A. Depaix, J. Kowalska, J. Jemielity. Chemical Modifications of mRNA Ends for Therapeutic Applications, Accounts of Chemical Research, 56, 20, 2814-2826 (2023). https://doi.org/10.1021/acs.accounts.3c00442
  • B. A. Wojtczak, M. Bednarczyk, P. J. Sikorski, A. Wojtczak, P. Surynt, J. Kowalska, J. Jemielity. Synthesis and Evaluation of Diguanosine Cap Analogs Modified at the C8-Position by Suzuki–Miyaura Cross-Coupling: Discovery of 7-Methylguanosine-Based Molecular Rotors, The Journal Organic Chemistry, 88, 11, 6827-6846 (2023). https://doi.org/10.1021/acs.joc.3c00126
  • M. Kozarski, K. Drazkowska, M. Bednarczyk, M. Warmisnki, J. Jemielity, J. Kowalska. Towards superior mRNA caps accessible by click chemistry: synthesis and translational properties of triazole-bearing oligonucleotide cap analogs, RSC Advances, 13, 12809-12824 (2023). https://doi.org/10.1039/D3RA00026E
  • A. Depaix, E. Grudzien-Nogalska, B. Fedorczyk, M. Kiledjian, J. Jemielity, J. Kowalska. Preparation of RNAs with non-canonical 5′ ends using novel di- and trinucleotide reagents for co-transcriptional capping, Frontiers in Molecular Biosciences, 9, 854170 (2022). https://doi.org/10.3389/fmolb.2022.854170
  • B. A. Wojtczak, P. J. Sikorski, K. Fac-Dabrowska, A. Nowicka, M. Warminski, D. Kubacka, E. Nowak, M. Nowotny, J. Kowalska, J. Jemielity. 5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes, Journal of American Chemical Society, 140, 18, 5987-5999 (2018). https://doi.org/10.1021/jacs.8b02597
  • A. Mamot, P. J. Sikorski, M. Warminski, J. Kowalska, J. Jemielity. Azido-Functionalized 5ʹ-Cap Analogs for Preparation of Translationally Active mRNAs Suitable for Fluorescent Labeling in Living Cells, Angewandte Chemie Int. Ed.,56, 49, 15628-15632 (2017). https://doi.org/10.1002/anie.201709052