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Prof. Christine Cardin

Prof. Christine Cardin

Professor of Crystallography

University of Reading

https://www.reading.ac.uk/chemistry/staff/professor-christine-cardin

Professional background: Christine Cardin received her academic training in the areas of bioinorganic and organometallic chemistry. She is an enthusiastic X-ray crystallographer since 1972, and holds many longstanding collaborations. Her research interests are in the are of nucleic acid structures, with a focus on the precise details of small molecule interactions, including the ruthenium polypyridyl “light-switch” and related metal complexes. She focuses on examining and understanding the molecular basis of the “light-switch” effect, and the development of new complexes. Her current projects are strongly collaborative, being both interdisciplinary and inter-institutional.

Selected publications:

  • M. Dalla Pozza, P. Mesdom, A. Abdullrahman, T. D. Prieto Otoya, P. Arnoux, C. Frochot, G. Niogret, B. Saubaméa, P. Burckel, J. P. Hall, M. Hollestein, C. J. Cardin, G. Gasser. Increasing the π-Expansive Ligands in Ruthenium(II) Polypyridyl Complexes: Synthesis, Characterization, and Biological Evaluation for Photodynamic Therapy Applications, Inorganic Chemistry, 62, 45, 18510-18523 (2023). https://doi.org/10.1021/acs.inorgchem.3c02606
  • K. T. McQuaid, A. Pipier, C. J. Cardin, D. Monchaud. Interactions of small molecules with DNA junctions, Nucleic Acids Research,50, 22, 12636-12656 (2022). https://doi.org/10.1093/nar/gkac1043
  • M. Dalla Pozza, A. Abdullrahman, C. Cardin, G. Gasser, J. P. Hall. Three’s a crowd – stabilisation, structure, and applications of DNA triplexes, Chemical Science, 13, 10193-10215 (2022). https://doi.org/10.1039/D2SC01793H
  • K. T. McQuaid, S. Takahashi, L. Baumgaertner, D. J. Cardin, N. G. Paterson, J. P. Hall, N. Sugimoto, C. J. Cardin. Ruthenium Polypyridyl Complex Bound to a Unimolecular Chair-Form G-Quadruplex. Journal of American Chemical Society, 144, 13, 5956-5964 (2022). https://doi.org/10.1021/jacs.2c00178
  • P. M. Keane, K. O’Sullivan, F. E. Poynton, B. C. Poulsen, I. V. Sazanovich, M. Towrie, C. J. Cardin, X. Sun, M. W. George, T. Gunnlaugsson, S. J. Quinn, J. M. Kelly. Understanding the factors controlling the photo-oxidation of natural DNA by enantiomerically pure intercalating ruthenium polypyridyl complexes through TA/TRIR studies with polydeoxynucleotides and mixed sequence oligodeoxynucleotides, Chemical Science, 11, 8600-8609 (2020). https://doi.org/10.1039/D0SC02413A
  • F. R. Baptista, S. J. Devereux, S. P. Gurung, J. P. Hall, I. V. Sazanovich, M. Towrie, C. J. Cardin, J. A. Brazier, J. M. Kelly, S. J. Quinn. The influence of loops on the binding of the [Ru(phen)2dppz]2+ light-switch compound to i-motif DNA structures revealed by time-resolved spectroscopy, Chemical Communications, 56, 9703-9706 (2020). https://doi.org/10.1039/D0CC03702H
  • K. McQuaid, J. P. Hall, L. Baumgaertner, D. J. Cardin, C. J. Cardin. Three thymine/adenine binding modes of the ruthenium complex Λ-[Ru(TAP)2(dppz)]2+ to the G-quadruplex forming sequence d(TAGGGTT) shown by X-ray crystallography, Chemical Communications, 55, 9116-9119 (2019). https://doi.org/10.1039/C9CC04316K